Kangaroo Island is a pretty safe place but care should be taken when driving around the island by car. Slow down less than 80 km/h is advised specifically around dusk and dawn but also during the night since wildlife is most active at this time. None of the car rental services cover damage caused by collision with animals so be extremely careful. Road conditions are good - most roads are sealed - though some tourist locations can only be reached on unsealed roads which are usually well graded. Unsealed roads are often made with an ironstone top which can making cars skid when turning or stopping at speed. Drivers inexperienced on unsealed roads should be extremely careful during wet conditions as traction in a standard two wheel drive vehicle is very poor. The island itself is approx 150km x 50km; allow plenty of time to travel to your destination.
Peninsula tiger snakes are common in parts. Particular in areas around Cape Willoughby - where some grassy areas are even closed to the public. Stick to paths if possible.